The use of local kelor (moringa oleifera) leaves powder from West Nusa Tenggara to increase the neutrophile cell phagocyte index and its function on rats with PEM infected by staphylococcus aureus

https://doi.org/10.21744/lingcure.v6nS4.2062

Authors

  • Luthfiyah Fifi Health Polytechnic Health Ministry of Malang, Malang, Indonesia
  • Sofiyatin Reni Health Polytechnic Health Ministry of Mataram, Mataram, Indonesia
  • Widjajanto Edi Brawijaya University, Malang, Indonesia
  • Taufiqurrahman Health Polytechnic Health Ministry of Surabaya, Surabaya, Indonesia

Keywords:

acute malnutrition, contagious diseases, local kelor, neutrophile index, staphylococcus aureus

Abstract

Indonesia is reportedly ranked third in the prevalence of acute malnutrition in the Asia Pacific. Protein Energy Malnutrition (PEM) has a high prevalence in the West Nusa Tenggara (NTB) Province with over600 cases reported by the Health Department from January to October 2015, especially among children under five of which 31 cases led to death. Meanwhile, the nutrition status is accurately determined through blood biochemical and hematology tests. The Neutrophil index is an important biomarker in combating infectious agents, such as Staphylococcus aureus which is often the cause of contagious diseases. Individuals suffering from Protein-Energy Malnutrition are most vulnerable to these types of infections. Fortunately, kelor (Moringaoleifera) has been found to have nutritious contents, especially protein and iron (Fe), but its potential has not been extensively explored in the West Nusa Tenggara. This study aims to confirm the effect of the local kelor (Moringa oleifera) leaves powder in increasing the Innate Immune Response of sample rats with Protein Energy Malnutrition (PEM). A post-test randomized control group design was used with 20 rats grouped into five with a period of 56 days.

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References

Agichtein, E., Castillo, C., Donato, D., Gionis, A., & Mishne, G. (2008, February). Finding high-quality content in social media. In Proceedings of the 2008 international conference on web search and data mining (pp. 183-194).

Amaglo, N. K., Timpo, G. M., Ellis, W. O., Bennett, R. N., & Foidl, N. (2006). Effect of spacing and harvest frequency on the growth and leaf yield of moringa (Moringa oleifera Lam.), a leafy vegetable crop. Ghana J. Hortic, 6(1), 33-40.

Barkema, H. W., Green, M. J., Bradley, A. J., & Zadoks, R. N. (2009). Invited review: The role of contagious disease in udder health. Journal of dairy science, 92(10), 4717-4729. https://doi.org/10.3168/jds.2009-2347

Breedveld, F. C., Lafeber, G. J., van den Barselaar, M. T., van Dissel, J. T., & Leijh, P. C. (1986). Phagocytosis and intracellular killing of Staphylococcus aureus by polymorphonuclear cells from synovial fluid of patients with rheumatoid arthritis. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 29(2), 166-173.

Budiono, I. (2013). Pengembangan Model Indeks Pembangunan Gizi. KEMAS: Jurnal Kesehatan Masyarakat, 8(2).

Choudhary, M. K., Bodakhe, S. H., & Gupta, S. K. (2013). Assessment of the antiulcer potential of Moringa oleifera root-bark extract in rats. Journal of acupuncture and meridian studies, 6(4), 214-220. https://doi.org/10.1016/j.jams.2013.07.003

Ciliberto, H., Ciliberto, M., Briend, A., Ashorn, P., Bier, D., & Manary, M. (2005). Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. Bmj, 330(7500), 1109.

Collins, S., Dent, N., Binns, P., Bahwere, P., Sadler, K., & Hallam, A. (2006). Management of severe acute malnutrition in children. The lancet, 368(9551), 1992-2000. https://doi.org/10.1016/S0140-6736(06)69443-9

Dima, L. R. (2016). Uji aktivitas antibakteri ekstrak daun kelor (Moringa oleifera L.) terhadap bakteri Escherichia coli dan Staphylococcus aureus. Pharmacon, 5(2).

Dos-Santos, M. A., Rosa, R., Curi, R., & Barbieri, D. H. G. P. (1997). Effect of protein malnutrition on the glycolytic and glutaminolytic enzyme activity of rat thymus and mesenteric lymph nodes. Brazilian Journal of Medical and Biological Research, 30, 719-722.

Fahey, J. W. (2005). Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees for life Journal, 1(5), 1-15.

Fatmawati, D., Puspitasari, P. K., & Yusuf, I. (2011). Efek Sitotoksik Ekstrak Etanol Sarang Semut (Myrmecodia pendens) Pada Sel Line Kanker Serviks HeLa Uji Eksperimental Secara In Vitro Cytotoxic Effect of Ethanolic Extract of Sarang Semut (Myrmecodia pendens) on HeLa Cervix Cancer Cell Line. Sains Medika, 3(2), 112-120.

Ferraz, D. F., & Monteiro, L. H. A. (2019). The impact of imported cases on the persistence of contagious diseases. Ecological Complexity, 40, 100788. https://doi.org/10.1016/j.ecocom.2019.100788

Gibson, R. S. (2005). Principles of nutritional assessment. Oxford university press, USA.

Golden, M. H. (1998). Oedematous malnutrition. British Medical Bulletin, 54(2), 433-444.

Harahap, N., Lubis, H. S., Siahaan, J., Hasibuan, A. L., & Nasution, L. Y. (2021). Tambar Ni Hulit: An ancient medical manuscript in North Sumatera: Local wisdom-based medicines with potential to be developed as Indonesian medicine. Linguistics and Culture Review, 5(S3), 1411-1425. https://doi.org/10.21744/lingcure.v5nS3.1833

Henningham, A., Döhrmann, S., Nizet, V., & Cole, J. N. (2015). Mechanisms of group A Streptococcus resistance to reactive oxygen species. FEMS microbiology reviews, 39(4), 488-508.

Hirayama, D., Iida, T., & Nakase, H. (2018). The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis. International journal of molecular sciences, 19(1), 92.

Katayon, S., Noor, M. M. M., Asma, M., Ghani, L. A., Thamer, A. M., Azni, I., ... & Suleyman, A. M. (2006). Effects of storage conditions of Moringa oleifera seeds on its performance in coagulation. Bioresource technology, 97(13), 1455-1460. https://doi.org/10.1016/j.biortech.2005.07.031

Kusmardi, K. S., & Wulandari, D. (2006). Pengaruh pemberian ekstrak etanol daun johar (Cassia siamea Lamk.) terhadap peningkatan aktivitas dan kapasitas fagositosis sel makrofag. Makara Kesehatan, 10(2), 89-93.

Lakonawa, K. Y., Sidiartha, I. G. L., & Pratiwi, I. G. A. P. E. (2020). Anemia and metabolic acidosis as risk factor of mortality in children with severe acute malnutrition. International Journal of Health Sciences, 4(3), 60-68. https://doi.org/10.29332/ijhs.v4n3.459

Lee, J. H., Kim, Y. G., Park, J. G., & Lee, J. (2017). Supercritical fluid extracts of Moringa oleifera and their unsaturated fatty acid components inhibit biofilm formation by Staphylococcus aureus. Food Control, 80, 74-82. https://doi.org/10.1016/j.foodcont.2017.04.035

Luthfiyah, F. (2012). Pengaruh serbuk daun kelor lokal nusa tenggara barat (NTB) pada tikus kurang gizi (evaluasi berat badan dan kadar albumin serum). Media Bina Ilmiah, 6, 42-50.

McMillan, A., Renaud, J. B., Burgess, K. M., Orimadegun, A. E., Akinyinka, O. O., Allen, S. J., ... & Sumarah, M. W. (2018). Aflatoxin exposure in Nigerian children with severe acute malnutrition. Food and Chemical Toxicology, 111, 356-362. https://doi.org/10.1016/j.fct.2017.11.030

Nájera, O., González, C., Toledo, G., López, L., & Ortiz, R. (2004). Flow cytometry study of lymphocyte subsets in malnourished and well-nourished children with bacterial infections. Clinical and Vaccine Immunology, 11(3), 577-580.

Nurul‘Ulum, A., Ulfah, M., & Sasmito, E. (2016). Uji Aktivitas Imunomodulator Fermentasi Teh Hitam Jamur Kombucha Terhadap Fagositosis Makrofag Mencit Galur Balb/c Secara in Vitro. Jurnal Ilmu Farmasi dan Farmasi Klinik, 13(2), 24-31.

Panneerselvam, S., & Govindasamy, S. (2003). Sodium molybdate improves the phagocytic function in alloxan-induced diabetic rats. Chemico-biological interactions, 145(2), 159-163. https://doi.org/10.1016/S0009-2797(02)00254-5

Parawansah, Nurtamin, T., Mulyawati, S. A., Nuralifah, & Misnaeni, W. O. A. (2018). Immunomodulatory Effect of Pare (Momordica charantia L.) Fruit Ethanol Extract on Phagocytic Activity and Capacity of Mice Peritoneal Macrophages. INDONESIAN BIOMEDICAL JOURNAL, 10(2), 144-147.

Sidiartha, I. G. L., & Pratiwi, I. G. A. P. E. (2018). Implementation of STRONGkids in identify risk of malnutrition in government hospital. International Journal of Health Sciences, 2(2), 18-24. https://doi.org/10.29332/ijhs.v2n2.117

Sigler, K., Chaloupka, J., Brozmanova, J., Stadler, N., & Höfer, M. (1999). Oxidative stress in microorganisms—I. Folia Microbiologica, 44(6), 587-624.

Suriaman, E., & Khasanah, S. (2017). Skrining aktivitas antibakteri daun kelor (Moringa oleifera), daun bidara laut (Strychnos ligustrina Blume), dan amoxicilin terhadap bakteri patogen Staphylococcus aureus. Jurnal Biota, 3(1), 21-25.

Tong, S. Y., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler Jr, V. G. (2015). Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clinical microbiology reviews, 28(3), 603-661.

Udikala, M., Verma, Y., Sushma, S. L., & Lal, S. (2017). Phytonutrient and pharmacological significance of Moringa oleifera. International Journal of Life-Sciences Scientific Research, 3(5), 1387-1391.

Upadhyay, P., Yadav, M. K., Mishra, S., Sharma, P., & Purohit, S. (2015). Moringa oleifera: A review of the medical evidence for its nutritional and pharmacological properties. International Journal of Research in Pharmacy & Science, (2).

Van de Giessen, A. W., van Santen-Verheuvel, M. G., Hengeveld, P. D., Bosch, T., Broens, E. M., & Reusken, C. B. E. M. (2009). Occurrence of methicillin-resistant Staphylococcus aureus in rats living on pig farms. Preventive veterinary medicine, 91(2-4), 270-273. https://doi.org/10.1016/j.prevetmed.2009.05.016

Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202

Wilson, C. (2019). The translation applied in intersemiotic study. Applied Translation, 13(1), 9–15. Retrieved from https://appliedtranslation.nyc/index.php/journal/article/view/45

Yuan, Y., Guo, N., Zhao, C., Shen, S., Bu, X., & Ye, H. (2014). Marrow mesenchymal stromal cells reduce methicillin-resistant Staphylococcus aureus infection in rat models. Cytotherapy, 16(1), 56-63. https://doi.org/10.1016/j.jcyt.2013.06.002

Zarosylo, V., Karelova, H., Kaplya, O., Denisova, L., & Muravyova, I. (2021). Administrative and criminal measures in the field of prevention and counteraction to the spread of coronavirus diseases in Ukraine and their results. Linguistics and Culture Review, 5(S4), 1985-1994. https://doi.org/10.21744/lingcure.v5nS4.1860

Published

2022-01-02

How to Cite

Fifi, L., Reni, S., Edi, W., & Taufiqurrahman, T. (2022). The use of local kelor (moringa oleifera) leaves powder from West Nusa Tenggara to increase the neutrophile cell phagocyte index and its function on rats with PEM infected by staphylococcus aureus. Linguistics and Culture Review, 6(S4), 75-86. https://doi.org/10.21744/lingcure.v6nS4.2062

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Research Articles